PXD014992 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Interactome of the TCF3-HLF fusion protein |
Description | Oncogenic chimeric transcription factors are central drivers in cancer. To understand how the TCF3-HLF fusion protein rewires the transcriptional landscape in t(17;19) positive leukemia, functional genetic and proteomic experiments were conducted. In this dataset, the protein-protein interactions of the endogenous TCF3-HLF complex were characterized by AP-MS. |
HostingRepository | PRIDE |
AnnounceDate | 2020-08-05 |
AnnouncementXML | Submission_2020-08-04_23:18:44.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabian Frommelt |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-08-12 02:23:35 | ID requested | |
⏵ 1 | 2020-08-04 23:18:45 | announced | |
Publication List
Huang Y, Mouttet B, Warnatz HJ, Risch T, Rietmann F, Frommelt F, Ngo QA, Dobay MP, Marovca B, Jenni S, Tsai YC, Matzk S, Amstislavskiy V, Schrappe M, Stanulla M, Gstaiger M, Bornhauser B, Yaspo ML, Bourquin JP, The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell, 36(6):630-644.e9(2019) [pubmed] |
Keyword List
submitter keyword: AP-MS, FLAG-tagged fusion protein |
Contact List
Jean-Pierre Bourquin |
contact affiliation | Pediatric Oncology, Children’s Research Centre, University Children’s Hospital Zurich, Zurich, Switzerland |
contact email | Jean-Pierre.Bourquin@kispi.uzh.ch |
lab head | |
Fabian Frommelt |
contact affiliation | ETH Zurich |
contact email | frommelt@imsb.biol.ethz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD014992 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014992
- Label: PRIDE project
- Name: Interactome of the TCF3-HLF fusion protein