PXD014991-2

PXD014991 is an original dataset announced via ProteomeXchange.

Title	Multiplexed Quantitative Proteomics Provides Mechanistic Cues for Malaria Severity and Complexity
Description	Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients. We identified a few parasite proteins in severe malaria patients, which could be promising from a diagnostic perspective. Further, from host proteome analysis we observed substantial modulations in many crucial physiological pathways, including lipid metabolism, cytokine signaling, complement, and coagulation cascades in severe malaria. We propose that severe manifestations of malaria are possibly underpinned by modulations of the host physiology and defense machinery, which is evidently reflected in the plasma proteome alterations. Importantly, we identified multiple blood markers that can effectively define different complications of severe falciparum malaria, including cerebral syndromes and severe anemia. The ability of our identified blood markers to distinguish different severe complications of malaria may aid in developing new clinical tests for monitoring malaria severity.
HostingRepository	PRIDE
AnnounceDate	2020-11-06
AnnouncementXML	Submission_2020-11-23_07:35:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vipin Kumar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-12 02:23:11	ID requested
1	2020-11-06 06:47:44	announced
⏵ 2	2020-11-23 07:35:03	announced	2020-11-23: Updated publication reference for PubMed record(s): 33204009.

Kumar V, Ray S, Aggarwal S, Biswas D, Jadhav M, Yadav R, Sabnis SV, Banerjee S, Talukdar A, Kochar SK, Shetty S, Sehgal K, Patankar S, Srivastava S, Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity. Commun Biol, 3(1):683(2020) [pubmed]

submitter keyword: Multiplexed Quantitative Proteomics, Severe Malaria, Infectious Disease,

Sanjeeva Srivastava
contact affiliation	Proteomics Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai-400076, India.
contact email	sanjeeva@iitb.ac.in
lab head
Vipin Kumar
contact affiliation	Research Scholar
contact email	vipin5@iitb.ac.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD014991

PRIDE project URI

• PRIDE
  1. PXD014991
     1. Label: PRIDE project
     2. Name: Multiplexed Quantitative Proteomics Provides Mechanistic Cues for Malaria Severity and Complexity