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PXD014883-1
PXD014883 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Vestibular schwannoma is comprised of neural crest and immune subgroups |
| Description | Vestibular schwannomas (VS) are tumors arising from cranial nerve Schwann cells that cause significant morbidity and are treated with surgery and irradiation. We describe a DNA methylation-based classification of VS into neural crest and immune enriched subgroups and validate our findings using bulk and single cell transcriptomics. Neural crest enriched VS express primary cilia and are associated with misactivation of the Hedgehog pathway. Irradiation epigenetically reprograms VS cells to reduce ciliary length, attenuate Hedgehog signaling, and induce cellular stress mechanisms that recruit lymphocytes and macrophages, transforming recurrent tumors in pairs of patient-matched samples from neural crest to immune enriched VS. Using single cell transcriptomics, we develop a VS cell atlas and identify a diversity of schwannoma and non-schwannoma cell-types that resemble different stages of nerve injury and regeneration. These data elucidate the molecular pathways underlying VS and establish a framework for understanding how irradiation modulates the tumor microenvironment. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-06-17 |
| AnnouncementXML | Submission_2026-06-17_14:36:20.135.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | supported by repository but incomplete data and/or metadata |
| PrimarySubmitter | Kuei-Ho Chen |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-08-01 16:36:51 | ID requested | |
| ⏵ 1 | 2026-06-17 14:36:20 | announced |
Publication List
| Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR, Epigenetic reprogramming shapes the cellular landscape of schwannoma. Nat Commun, 15(1):476(2024) [pubmed] |
Keyword List
| submitter keyword: Vestibular schwannomas, transcriptomics, stereotactic radiosurgery, CRISPR interference, RNA sequencing, DNA methylation arrays, Label-free quantification, Parallel reaction monitoring |
Contact List
| Kuei-Ho Chen | |
|---|---|
| contact affiliation | J. David Gladstone Institutes, San Francisco, CA |
| contact email | kueiho.chen@gladstone.ucsf.edu |
| lab head | |
| Kuei-Ho Chen | |
| contact affiliation | J. David Gladstone Institutes, San Francisco, CA |
| contact email | kueiho.chen@gladstone.ucsf.edu |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
