PXD014875-1

PXD014875 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased translation, keratinocyte-immune crosstalk and disordered axon guidance
Description	Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Skin as an organ which can be modelled using primary cells in vitro provides the opportunity for selected genetic effects to be investigated in detail.
HostingRepository	PRIDE
AnnounceDate	2019-08-14
AnnouncementXML	Submission_2019-08-14_06:03:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sara ten Have
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-01 03:36:47	ID requested
⏵ 1	2019-08-14 06:03:23	announced
2	2019-10-25 04:10:37	announced	2019-10-25: Updated publication reference for PubMed record(s): 31641698.
3	2024-10-22 04:57:54	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: human, Skin, Atopic Eczema

Sara Brown
contact affiliation	Skin Research Group, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK
contact email	s.j.brown@dundee.ac.uk
lab head
Sara ten Have
contact affiliation	The Centre for Gene Regulation and Expression
contact email	s.m.tenhave@dundee.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD014875

PRIDE project URI

• PRIDE
  1. PXD014875
     1. Label: PRIDE project
     2. Name: Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased translation, keratinocyte-immune crosstalk and disordered axon guidance