PXD014865-1

PXD014865 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomic analysis of neonatal regenerative myocardium revealed important roles of CHK1 via activating mTORC1/P70S6K pathway
Description	Restoring the regenerative capacity of myocardium, which presents shortly in the newborns but lost in adulthood, is one of the therapeutic options for myocardial repair post various insults. In this work, we performed the phosphoproteomic analysis on neonatal regenerative myocardium and explored the Kinase-substrate network in neonatal myocardium to define potential signaling, which might be responsible for the transient regenerative capacity in the newborn mice.
HostingRepository	PRIDE
AnnounceDate	2020-02-28
AnnouncementXML	Submission_2020-02-28_00:49:35.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yiwei Cheng
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-01 01:23:17	ID requested
⏵ 1	2020-02-28 00:49:36	announced
2	2024-10-22 04:57:45	announced	2024-10-22: Updated project metadata.

Fan Y, Cheng Y, Li Y, Chen B, Wang Z, Wei T, Zhang H, Guo Y, Wang Q, Wei Y, Chen F, Sha J, Guo X, Wang L, Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway. Circulation, 141(19):1554-1569(2020) [pubmed]

submitter keyword: Quantitative phosphoproteomics

neonatal myocardium

regeneration

CHK1

cardiac myocyte.

Xuejiang Guo
contact affiliation	State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China.
contact email	guo_xuejiang@njmu.edu.cn
lab head
Yiwei Cheng
contact affiliation	Nanjing Medical University
contact email	chengyiwei1990@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD014865

PRIDE project URI

• PRIDE
  1. PXD014865
     1. Label: PRIDE project
     2. Name: Phosphoproteomic analysis of neonatal regenerative myocardium revealed important roles of CHK1 via activating mTORC1/P70S6K pathway