PXD014817-1
PXD014817 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcription |
| Description | The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance. Here, we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression. Elevated TRIB3 expression supports BCSCs by interacting with AKT to interfere with the FOXO1-AKT interaction and suppress FOXO1 phosphorylation, ubiquitination, and degradation by E3 ligases SKP2 and NEDD4L. The accumulated FOXO1 promotes transcriptional expression of SOX2, a transcriptional factor for cancer stemness, which in turn, activates FOXO1 transcription and forms a positive regulatory loop. Disturbing the TRIB3-AKT interaction suppresses BCSCs by accelerating FOXO1 degradation and reducing SOX2 expression in mouse models of breast cancer. Our study provides insights into breast cancer development and confers a potential therapeutic strategy against TRIB3-overexpressed breast cancer. |
| HostingRepository | iProX |
| AnnounceDate | 2019-07-30 |
| AnnouncementXML | Submission_2019-09-18_19:56:52.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jinmei Yu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-07-30 00:29:41 | ID requested | |
| ⏵ 1 | 2019-09-18 19:56:53 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: FOXO1 Interacting protein |
Contact List
| Bing Cui | |
|---|---|
| contact affiliation | Institute of Materia Medica |
| contact email | cuibing@imm.ac.cn |
| lab head | |
| Jinmei Yu | |
| contact affiliation | Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College |
| contact email | yujinmei198303@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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