PXD014691 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | IFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation |
| Description | B cell receptor (BCR) signaling and oncogenic tyrosine kinases that mimic BCR-signaling in B-lineage leukemia and lymphoma depend on assembly of membrane proximal signaling complexes. Signalosomes in normal BCR- and oncogene (e.g. BCR-ABL1, RAS-pathway lesions) signal transduction are recruited to phospholipid anchors in lipid rafts. The robustness of these complexes depends on cholesterol accumulation in lipid rafts. Here we identified the interferon-induced transmembrane protein IFITM3 as a central regulator of cholesterol in lipid rafts. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_05:16:54.475.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Matthew Nix |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2019-07-22 05:55:27 | ID requested | |
| 1 | 2020-12-17 23:26:41 | announced | |
| ⏵ 2 | 2024-10-22 05:16:55 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: leukemia, BCR signaling, cell surface, lipid rafts |
Contact List
| Arun Wiita |
|---|
| contact affiliation | Department of Laboratory Medicine, UCSF |
| contact email | arun.wiita@ucsf.edu |
| lab head | |
| Matthew Nix |
|---|
| contact affiliation | UCSF |
| contact email | matthew.nix@ucsf.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD014691 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014691
- Label: PRIDE project
- Name: IFITM3-mediated regulation of cell membrane dynamics is essential for malignant B-cell transformation
