PXD014636 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex |
Description | ZEILUPE (ZTL), a blue light photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day light conditions to the circadian clock. To function properly, ZTL protein must accumulate but not destablilize target clock transcription factors before dusk, while in the dark ZTL mediates degradation of target proteins. It is not clear how ZTL can accumulate to high levels in the ligh while its targets remain stable. Two deubiquitylating enzymes, UBIQUITIN-SPECIFIC PROTEASE 12 and UBIQUITIN-SPECIFIC PROTEASE 13 (UBP12 and UBP13), which regulate colock period and protein ubiquitylation in a manner opposite to ZTL, were shown to associate with the ZTL protein complex. Here we demonstrate that the ZTL light-dependent interacting partner GIGANTEA (GI), recruites UBP12 and UBP13 to the ZTL photoreceptor complex. |
HostingRepository | PRIDE |
AnnounceDate | 2019-08-22 |
AnnouncementXML | Submission_2019-08-30_00:42:17.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Man Wah Li |
SpeciesList | scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-16 07:54:00 | ID requested | |
1 | 2019-08-22 03:22:41 | announced | |
⏵ 2 | 2019-08-30 00:42:18 | announced | Updated publication reference for PubMed record(s): 31434902. |
Publication List
Lee CM, Li MW, Feke A, Liu W, Saffer AM, Gendron JM, GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex. Nat Commun, 10(1):3750(2019) [pubmed] |
Keyword List
submitter keyword: Arabidopsis, GIGANTEA, UBP, ZEITLUPE, Circadian Clock, Deubiquitylases |
Contact List
Joshua M Gendron |
contact affiliation | Yale University |
contact email | joshua.gendron@yale.edu |
lab head | |
Man Wah Li |
contact affiliation | Yale University |
contact email | limanwah@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD014636
- Label: PRIDE project
- Name: GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex