PXD014579-2

PXD014579 is an original dataset announced via ProteomeXchange.

Title	Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping
Description	Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results revealed that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells, leading to the description of potential informative sEV-associated biomarkers for GBM subtyping, such as CD44. Overall, these data could assist future GBM in vitro studies and provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:50:19.980.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Simon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-11 07:59:34	ID requested
1	2019-08-08 08:14:12	announced
⏵ 2	2023-11-14 08:50:20	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: extracellular vesicles,Glioblastoma, biomarkers

Prof Georgios Giamas
contact affiliation	Giamas Lab School of Life Sciences University of Sussex
contact email	g.giamas@sussex.ac.uk
lab head
Thomas Simon
contact affiliation	University of Sussex
contact email	t.simon@sussex.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD014579
     1. Label: PRIDE project
     2. Name: Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping