PXD014517-1

PXD014517 is an original dataset announced via ProteomeXchange.

Title	Role of Y1212 VEGFR2 signaling transduction
Description	The project concerns vascular endothelial growth factor (VEGF) signaling, which is dependent on binding of VEGF to VEGF receptor-2 (VEGFR2) and leads to activation of the receptor kinase and autophosphorylation. Previous mouse studies with the VEGFR-2 phosphorylation site mutation Y1212F showed reduced vascular stability. We here investigate with LC-MS proteomics which signal transduction pathway(s) are lost in the mutant by identifying proteins that bind to the Y1212F site.
HostingRepository	PRIDE
AnnounceDate	2019-08-13
AnnouncementXML	Submission_2019-08-13_00:24:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Branca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-08 03:52:13	ID requested
⏵ 1	2019-08-13 00:24:29	announced

Dataset with its publication pending

submitter keyword: Human, HDMEC, VEGFR2, signaling, LC-MS, proteomics

Janne Lehtiö
contact affiliation	Clinical proteomics, Oncology-Pathology department, Karolinska Institutet
contact email	janne.lehtio@ki.se
lab head
Rui Branca
contact affiliation	Clinical Proteomics Unit, Dep. of Oncology-Pathology
contact email	rui.mamede-branca@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD014517

PRIDE project URI

• PRIDE
  1. PXD014517
     1. Label: PRIDE project
     2. Name: Role of Y1212 VEGFR2 signaling transduction