PXD014485-1

PXD014485 is an original dataset announced via ProteomeXchange.

Title	Thermal proteome profiling of anti-HEV compound
Description	We performed thermal proteome profiling (TPP) to identify targets of a new anti hepatitis E virus compound.
HostingRepository	PRIDE
AnnounceDate	2021-03-04
AnnouncementXML	Submission_2021-03-04_10:52:20.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andre Mateus
SpeciesList	scientific name: Hepatitis E virus type 1; NCBI TaxID: 185579; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-04 07:02:40	ID requested
⏵ 1	2021-03-04 10:52:21	announced
2	2024-10-22 05:17:16	announced	2024-10-22: Updated project metadata.

Nimgaonkar I, Archer NF, Becher I, Shahrad M, LeDesma RA, Mateus A, Caballero-G, ó, mez J, Berneshawi AR, Ding Q, Douam F, Gaska JM, Savitski MM, Kim H, Ploss A, Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res, 185():104997(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: thermal proteome profiling, drugs, target engagement

Alexander Ploss
contact affiliation	Princeton University
contact email	aploss@princeton.edu
lab head
Andre Mateus
contact affiliation	European Molecular Biology Laboratory
contact email	andre.mateus@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD014485

PRIDE project URI

• PRIDE
  1. PXD014485
     1. Label: PRIDE project
     2. Name: Thermal proteome profiling of anti-HEV compound