PXD014413 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics survey of Streptomyces coelicolor strains with natural gross chromosome change |
Description | Streptomyces coelicolor normally produce spores with a relatively high heterogeneity, which will produce genetically heterogeneous sub-populations. These sub-populations often exert massive chromosome amplifications and deletions. Cells with gross chromosomal changes produce an increased diversity of secondary metabolites and secrete significantly more antibiotics; however, these changes come at the cost of dramatically reduced individual fitness, providing direct evidence for a trade-off between secondary metabolite production and fitness. We propose that antibiotic production in colonies of the multicellular bacterium Streptomyces coelicolor is coordinated by a division of labour. This proteomics survey will provide more detailed insights into how these chromosomal changed strains behave under normal growth condition. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-26 |
AnnouncementXML | Submission_2020-05-26_14:34:31.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD014413 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Chao DU |
SpeciesList | scientific name: Streptomyces coelicolor; NCBI TaxID: 1902; |
ModificationList | Carbamidomethyl |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-06-27 08:32:07 | ID requested | |
⏵ 1 | 2020-05-26 14:34:32 | announced | |
Publication List
Zhang Z, Du C, de Barsy F, Liem M, Liakopoulos A, van Wezel GP, Choi YH, Claessen D, Rozen DE, is organized by a division of labor through terminal genomic differentiation. Sci Adv, 6(3):eaay5781(2020) [pubmed] |
Keyword List
submitter keyword: Division of labour, Chromosome change, Bacteria social behavior, Antibiotics over-production, Streptomyces coelicolor, |
Contact List
Gilles P. van Wezel |
contact affiliation | Institute of Biology Leiden, Leiden University |
contact email | g.wezel@biology.leidenuniv.nl |
lab head | |
Chao DU |
contact affiliation | Leiden University |
contact email | c.du@biology.leidenuniv.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD014413 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014413
- Label: PRIDE project
- Name: Proteomics survey of Streptomyces coelicolor strains with natural gross chromosome change