PXD014350-1

PXD014350 is an original dataset announced via ProteomeXchange.

Title	QUANTITATIVE SUBCELLULAR PROTEOMICS OF THE ORBITOFRONTAL CORTEX OF SCHIZOPHRENIA PATIENTS
Description	We analyzed OFC post-mortem brain tissue from patients classified as residual schizophrenia according to the DMS-IV manual. In this classification, the patients do not manifest prominent positive psychotic symptoms but prevail characteristic disturbance of negative symptoms. Through the comparison of patient´s samples against a pool of control subjects without any history of psychiatric illness we generated an organellar proteome map from different subcellular fractions such as mitochondria (MIT), crude nuclear fraction (NUC) and cytoplasm (CYT) with the aim to monitor the subproteome changes using iTRAQ labelling for relative quantification and Selected Reaction Monitoring (SRM) for targeted quantification.
HostingRepository	PRIDE
AnnounceDate	2019-10-07
AnnouncementXML	Submission_2019-10-07_02:12:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Proteomics Unit
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-24 02:37:22	ID requested
⏵ 1	2019-10-07 02:12:55	announced
2	2024-10-22 04:11:35	announced	2024-10-22: Updated project metadata.

Vel, á, squez E, Martins-de-Souza D, Vel, á, squez I, Carneiro GRA, Schmitt A, Falkai P, Domont GB, Nogueira FCS, Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients. J Proteome Res, 18(12):4240-4253(2019) [pubmed]

submitter keyword: Schizophrenia, cellular fractions, proteomics, quantification

Fabio Nogueira
contact affiliation	Department of Biochemistry, Institute of Chemistry, Federal university of Rio de Janeiro
contact email	fabiocsn@gmail.com
lab head
Proteomics Unit
contact affiliation	UFRJ
contact email	unidadeproteomica@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD014350

PRIDE project URI

• PRIDE
  1. PXD014350
     1. Label: PRIDE project
     2. Name: QUANTITATIVE SUBCELLULAR PROTEOMICS OF THE ORBITOFRONTAL CORTEX OF SCHIZOPHRENIA PATIENTS