PXD014228 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effects of N-acetylcysteine on the neurotoxicity induced by acute exposure to acrylamide |
Description | In this study, we used the adult zebrafish model of ACR acute neurotoxicity for determining the suitability of NAC to protect the brain against ACR toxicity. First, the potential protective effects of NAC on the ACR neurotoxicity were evaluated at the behavioral and molecular (transcriptome and proteome) levels. Then, in order to understand the mild to negligible protective effect of NAC, the ability of this drug to cross BBB by passive diffusion was evaluated by different approaches. Whereas the BBB parallel artificial membrane permeability assay (BBB-PAMPA) was used to determine the ability of NAC to cross BBB-like phospholipid membranes by passive diffusion, the determination of the NAC content in the brain provides direct evidences of the BBB permeability in vivo. Finally, we evaluated the ability of drug to recover the depleted GSx stores and to scavenge ACR in the brain of ACR-exposed fish. |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-26 |
AnnouncementXML | Submission_2020-05-26_14:28:58.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tamar Ziv |
SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; |
ModificationList | S-carboxamidoethyl-L-cysteine; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-06-12 03:15:29 | ID requested | |
⏵ 1 | 2020-05-26 14:29:00 | announced | |
Publication List
Faria M, Prats E, G, ó, mez-Canela C, Hsu CY, Arick MA, Bedrossiantz J, Orozco M, Garcia-Reyero N, Ziv T, Ben-Lulu S, Admon A, G, ó, mez-Oliv, á, n LM, Rald, ú, a D, Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Sci Rep, 9(1):16467(2019) [pubmed] |
Keyword List
submitter keyword: Danio, acetylcysteine, acrylamide, neurotoxicity |
Contact List
Demetrio Raldua Perez |
contact affiliation | aInstitute for Environmental Assessment and Water Research (IDAEA-CSIC). Jordi Girona, 18. 08034 Barcelona, Spain |
contact email | drpqam@cid.csic.es |
lab head | |
Tamar Ziv |
contact affiliation | Technion |
contact email | tamarz@tx.technion.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014228
- Label: PRIDE project
- Name: Effects of N-acetylcysteine on the neurotoxicity induced by acute exposure to acrylamide