PXD014079-1

PXD014079 is an original dataset announced via ProteomeXchange.

Title	Integrated multi-omics analysis of zinc deficiency
Description	Zinc is an essential trace micronutrient and exerts important physiological and biochemical roles. Zinc deficiency is a global public-health problem. Standing untreated zinc deficiency can cause series adverse effects, including growth retardation, poor appetite, delayed sexual development, impaired neurologic and immune systems, diabetes and obesity, et al. However, the underlying mechanisms of these adverse effects remain elusive in most cases and a comprehensive understanding of the adverse effects (known and unknown) induced by zinc deficiency is lacking. As we know, zinc is a critical component of over 3000 enzymes and is required for numerous catalytic, structural, and regulatory functions of proteins. Thus, the impairments in enzyme actions are responsible for the gross symptoms of zinc deficiency. Altered enzymes may induce to the extensive changes in diverse molecular components of body, including DNA, mRNA and metabolites; and all above changes may work together to induce the adverse effects and affect the health of body. Therefore, protein changes associated with zinc deficiency are very necessary to be unraveled and described for revealing the known and unknown adverse effects and underlying mechanisms. In this project, we first performed a multi-omics study by integrating plasma metabolomics and proteomics, liver proteomics and metal ionomics on zinc deficient rats in order to identify biomarkers (proteins, metabolites and metal elements) of zinc deficiency and reveal the changed metabolic pathways. Eventually, we expected to completely present known adverse effects and their underlying molecular mechanisms, and uncover unknown adverse effects of zinc deficiency.
HostingRepository	iProX
AnnounceDate	2019-06-05
AnnouncementXML	Submission_2023-08-27_21:08:19.638.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maoqing Wang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-31 00:11:09	ID requested
⏵ 1	2023-08-27 21:08:21	announced

Wang M, Fan L, Wei W, Wang P, Yu Q, Long Z, Sun Y, Li Z, Zi T, Dong F, Sun Z, Song X, Sun C, Li Y, Wang F, Integrated multi-omics uncovers reliable potential biomarkers and adverse effects of zinc deficiency. Clin Nutr, 40(5):2683-2696(2021) [pubmed]

submitter keyword: Zinc deficiency,proteomics,TMT isobaric labeling

Maoqing Wang
contact affiliation	National Key Disciplines of Nutrition and Food Hygiene, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
contact email	wang_maoqing@126.com
lab head
Maoqing Wang
contact affiliation	National Key Disciplines of Nutrition and Food Hygiene, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
contact email	wang_maoqing@126.com
dataset submitter

iProX dataset URI