PXD014063-2

PXD014063 is an original dataset announced via ProteomeXchange.

Title	HDA714 is a versatile protein lysine deacetylase regulating metabolic and translational activities
Description	The rice genome encodes 18 HDACs from the three different families. The RPD3 family comprises 14 genes, the HDT and the Sir families contain each 2 genes. Previous studies showed that rice RPD3 members are involved in various developmental processes. In this work, we used quantitative proteomics to investigate the acetylomes regulated by rice rpd3 family HDAC proteins in seedlings. Our results establish an unprecedentedly comprehensive protein acetylome in plants and reveal that HDA714 is a major deacetylase targeting a large number of Kac sites on hundreds of proteins of diverse function. We show that HDA714-dependent deacetylation is required for glycolytic activity, ribosome translational function, and plant growth and development. Our data uncovers novel regulators of protein Kac homeostasis in plants and extends the role of protein Kac in gene expression to translational regulation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:20:16.015.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	qiutao xu
SpeciesList	scientific name: Oryza sativa (Rice); NCBI TaxID: 4530;
ModificationList	acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-29 05:15:41	ID requested
1	2021-03-23 20:32:41	announced
⏵ 2	2024-10-22 05:20:16	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Rice； acetylation； histone deacetylase ；Ribo_seq

zhou dao xiu
contact affiliation	National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China
contact email	dxzhou@mail.hzau.edu.cn
lab head
qiutao xu
contact affiliation	Huazhong Agricultural University
contact email	skyyks123@webmail.hzau.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD014063
     1. Label: PRIDE project
     2. Name: HDA714 is a versatile protein lysine deacetylase regulating metabolic and translational activities