PXD013919-2

PXD013919 is an original dataset announced via ProteomeXchange.

Title	The proteomes of oral cells alter during co-cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens The proteomes of oral cells alter during co-cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens
Description	Although periodontitis is a widespread disease, its molecular mechanisms in human oral cells are not fully understood. Therefore, we established cell lines from the human oral cavity, including gingival keratinocytes (GK), osteoblastic lineage cells from the alveolar bone (OLAB), PDL fibroblasts (PDLF) and cementum cells (CC). Using label-free quantitative mass spectrometry, we investigated changes of the proteome of healthy human oral cells after co-cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens for 24 h, for the first time. Our findings show specific protein profiles for each of the human oral cell lines. This will help to understand pathologic mechanisms in periodontitis and related diseases, such as rheumatoid arthritis, diabetes mellitus or atherosclerotic vascular diseases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:02.080.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christof Lenz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-20 00:43:38	ID requested
1	2023-05-10 09:32:29	announced
⏵ 2	2023-11-14 08:46:04	announced	2023-11-14: Updated project metadata.

Schminke B, Kauffmann P, Brockmeyer P, Miosge N, Lenz C, Schubert A, . Biomedicines, 11(3):(2023) [pubmed]

curator keyword: Biomedical

submitter keyword: cementoblast, PDL fibroblast, bacteria, osteoblastic lineage cell,proteome, gingival keratinocyte

Christof Lenz
contact affiliation	University Medical Center Göttingen, Germany
contact email	christof.lenz@mpibpc.mpg.de
lab head
Christof Lenz
contact affiliation	Max Planck Institute for Biophysical Chemistry
contact email	christof.lenz@mpibpc.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD013919

PRIDE project URI

• PRIDE
  1. PXD013919
     1. Label: PRIDE project
     2. Name: The proteomes of oral cells alter during co-cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens The proteomes of oral cells alter during co-cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens