PXD013907-1

PXD013907 is an original dataset announced via ProteomeXchange.

Title	The dynamic configuration and phosphorylation of the C-terminal HEAT domain of huntingtin modulates its function
Description	Chemical cross-linking coupled to mass spectrometry was used to study different forms of human huntingtin (HTT). The variants included wild-type protein with poly-Q tail lengths of 23 and 78 and Ser2116 > Ala mutation of Q23- and Q78-HTT. Cross-linking was performed using the homobifunctional, lysine-reactive disuccinimidyl suberate (DSS).
HostingRepository	PRIDE
AnnounceDate	2020-07-07
AnnouncementXML	Submission_2020-07-07_04:31:12.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Leitner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-17 07:47:49	ID requested
⏵ 1	2020-07-07 04:31:12	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Chemical cross-linking

DSS

structural proteomics

huntingtin

Ji-Joon Song
contact affiliation	Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea
contact email	songj@kaist.ac.kr
lab head
Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD013907

PRIDE project URI

• PRIDE
  1. PXD013907
     1. Label: PRIDE project
     2. Name: The dynamic configuration and phosphorylation of the C-terminal HEAT domain of huntingtin modulates its function