PXD013838-4

PXD013838 is an original dataset announced via ProteomeXchange.

Title	Enamel proteome shows that Gigantopithecus was an early diverging pongine
Description	Gigantopithecus blacki was a giant hominid that inhabited Southeast Asia during the Pleistocene. Its evolutionary relationship to other great ape species, and their divergence during the Middle and Late Miocene (16-5.3 Mya), remains disputed. In part, this is due to the absence of cranial and postcranial remains and size-induced allometry. Proposed hypothesis on the phylogenetic positions of Gigantopithecus have therefore been wide-ranging among hominoids, but none has received independent validation based on molecular evidence. To clarify the phylogenetic placement of Gigantopithecus blacki, we retrieved enamel proteome sequences from a 1.9 million years (Mya) old molar found in Chuifeng Cave, China. We demonstrate that Gigantopithecus is most closely related to orangutans (genus Pongo). We also estimate the Gigantopithecus-Pongo divergence to about 10-12 Mya, implying its speciation is part of the Miocene radiation of great apes. These sequences are approximately 6 times older, in a normalized thermal context, than any previously published mammalian proteome or genome. The survival of an Early Pleistocene dental enamel proteome in the subtropics further expands the scope of palaeoproteomic analysis into geographic areas and time periods previously considered incompatible with biomolecular preservation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:56:31.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frido Welker
SpeciesList	scientific name: Hominidae; NCBI TaxID: 9604;
ModificationList	phosphorylated residue; monohydroxylated residue; monohydroxylated proline; deamidated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-14 02:15:41	ID requested
1	2019-11-12 02:27:20	announced
2	2019-11-18 01:07:48	announced	2019-11-18: Updated publication reference for PubMed record(s): 31723270.
3	2019-11-27 03:03:13	announced	2019-11-27: Updated project metadata.
⏵ 4	2024-10-22 04:56:37	announced	2024-10-22: Updated project metadata.

Welker F, Ramos-Madrigal J, Kuhlwilm M, Liao W, Gutenbrunner P, de Manuel M, Samodova D, Mackie M, Allentoft ME, Bacon AM, Collins MJ, Cox J, Lalueza-Fox C, Olsen JV, Demeter F, Wang W, Marques-Bonet T, Cappellini E, Enamel proteome shows that Gigantopithecus was an early diverging pongine. Nature, 576(7786):262-265(2019) [pubmed]

10.1038/s41586-019-1728-8;

submitter keyword: enamel, Pleistocene, Gigantopithecus,LC-MSMS

Enrico Cappellini
contact affiliation	Department of Biology, University of Copenhagen, Denmark.
contact email	ecappellini@bio.ku.dk
lab head
Frido Welker
contact affiliation	Postdoc Department of Biology, University of Copenhagen
contact email	frido.welker@palaeo.eu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD013838

PRIDE project URI

• PRIDE
  1. PXD013838
     1. Label: PRIDE project
     2. Name: Enamel proteome shows that Gigantopithecus was an early diverging pongine