PXD013805 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Antagonistic interactions between benzo[a]pyrene and C60 in toxicological response of Marine Mussel |
Description | his integrated study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into mussel tissues was confirmed by GC-MS, LC-HRMS and ICP-MS. Biomarkers of DNA damage as well as proteomics analysis were applied to unravel the toxic effect of B[a]P and C60. Antagonistic responses were observed at the genotoxic and proteomic level. Differentially expressed proteins (DEPs) were only identified in the B[a]P single exposure and the B[a]P mixture exposure groups containing 1 mg/L of C60, the majority of which were down-regulated (~52 %). No DEPs were identified at any of the concentrations of nC60 (p < 0.05, 1 % FDR). Using DEPs identified at a threshold of (p < 0.05; B[a]P and B[a]P mixture with nC60), gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis indicated that these proteins were enriched with a broad spectrum of biological processes and pathways, including those broadly associated with protein processing, cellular processes and environmental information processing. Among those significantly enriched pathways, the ribosome was consistently the top enriched term irrespective of treatment or concentration and plays an important role as the site of biological protein synthesis and translation. Our results demonstrate the complex multi-modal response to environmental stressors in M. galloprovincialis. |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-18 |
AnnouncementXML | Submission_2019-07-18_07:25:54.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD013805 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Laura Langan |
SpeciesList | scientific name: Mytilus galloprovincialis; NCBI TaxID: 29158; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-13 05:21:20 | ID requested | |
⏵ 1 | 2019-07-18 07:25:55 | announced | |
Publication List
Barranger A, Langan LM, Sharma V, Rance GA, Aminot Y, Weston NJ, Akcha F, Moore MN, Arlt VM, Khlobystov AN, Readman JW, Jha AN, ) in Toxicological Response of Marine Mussels. Nanomaterials (Basel), 9(7):(2019) [pubmed] |
Keyword List
submitter keyword: Trojan Horse effect, B[a]P, nC60, co-exposure, mussels, DNA damage, proteomics |
Contact List
Awadhesh N. Jha |
contact affiliation | Professor of Genetic Toxicology and Ecotoxicology School of Biological and Marine Science Plymouth University Plymouth United Kingdom |
contact email | a.jha@plymouth.ac.uk |
lab head | |
Laura Langan |
contact affiliation | Baylor University |
contact email | LAURA_LANGAN@BAYLOR.EDU |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013805
- Label: PRIDE project
- Name: Antagonistic interactions between benzo[a]pyrene and C60 in toxicological response of Marine Mussel