PXD013785-2

PXD013785 is an original dataset announced via ProteomeXchange.

Title	Dynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
Description	Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear blood cell have remained poorly defined. Using mass spectrometry-based quantitative proteomics combined with transcriptomic data, we report on the dynamic changes of 5 developmental stages in the bone marrow and blood. Integration of transcriptomic and proteomic unveiled highly dynamic and differential interactions between RNA and protein kinetics during human neutrophil development which could be linked to functional maturation of typical end-stage blood neutrophil killing activities.
HostingRepository	PRIDE
AnnounceDate	2019-11-07
AnnouncementXML	Submission_2020-09-28_00:22:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maartje van den Biggelaar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-09 06:27:30	ID requested
1	2019-11-07 08:05:08	announced
⏵ 2	2020-09-28 00:22:46	announced	2020-09-28: Updated publication reference for PubMed record(s): 31747616.
3	2024-10-22 04:15:21	announced	2024-10-22: Updated project metadata.

Hoogendijk AJ, Pourfarzad F, Aarts CEM, Tool ATJ, Hiemstra IH, Grassi L, Frontini M, Meijer AB, van den Biggelaar M, Kuijpers TW, Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep, 29(8):2505-2519.e4(2019) [pubmed]

submitter keyword: Proteomics,Transcriptomics, neutriphils, myeloid differentiation

M. van den Biggelaar
contact affiliation	Department of Molecular and Cellular Hemostasis, Sanquin Research Amsterdam, NL
contact email	m.vandenbiggelaar@sanquin.nl
lab head
Maartje van den Biggelaar
contact affiliation	Sanquin Research
contact email	m.vandenbiggelaar@sanquin.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD013785

PRIDE project URI

• PRIDE
  1. PXD013785
     1. Label: PRIDE project
     2. Name: Dynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming