PXD013738 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Striatal micro-punches of Ftofl/fl and FtoDeltaA2a mice. |
Description | Variations in the human FTO gene have been linked to obesity and altered connectivity and function of the dopaminergic neurocircuitry. Here we report that FTO in D2 medium spiny neurons (MSNs) of mice regulates the excitability of these cells in vitro and in vivo as well as controls D2 MSN globus pallidus external projections. Lack of FTO in D2 MSNs translates into increased locomotor responses to novelty, associated with altered timing behavior without affecting reward responses to drugs of abuse and highly palatable food, or the ability to discount rewards. Pharmacological manipulation of D1R- and D2R-dependent pathways in these animals reveals an altered balance between D1 MSN- and D2 MSN-mediated control of motor output. These findings hold the potential to target a novel avenue for control of basal ganglia motor function, where modulation of FTO-dependent signaling in D2 MSNs may promote D1 MSN regulated locomotor behavior without altering reward signaling or inciting impulsivity. |
HostingRepository | PRIDE |
AnnounceDate | 2019-06-14 |
AnnouncementXML | Submission_2019-06-14_05:23:59.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hendrik Nolte |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-07 03:42:35 | ID requested | |
⏵ 1 | 2019-06-14 05:24:00 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Striatum, LC-MS/MS, FTO |
Contact List
Marcus Krüger |
contact affiliation | Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany. |
contact email | marcus.krueger@uni-koeln.de |
lab head | |
Hendrik Nolte |
contact affiliation | Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) |
contact email | h.nolte@uni-koeln.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013738
- Label: PRIDE project
- Name: Striatal micro-punches of Ftofl/fl and FtoDeltaA2a mice.