PXD013730 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Trrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity |
Description | The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 target genes. Modulation of Sp1 function by Trrap acts as a hub regulating multiple processes involved in neuron and neural stem cells function and maintenance including microtubule dynamics and the Wnt signaling pathway. Consistently, Trrap conditional mutants exhibit all hallmarks of neurodegeneration including dendrite retraction and axonal swellings, neuron death, astrogliosis, microglia activation, demyelination and decreased adult neurogenesis. Our results uncovered a novel functional network, essential to prevent neurodegeneration, and involving the specific regulation of Sp1 transcription factor by Trrap-HAT. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-02 |
AnnouncementXML | Submission_2021-03-02_10:24:24.364.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joanna Kirkpatrick |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-07 02:47:00 | ID requested | |
⏵ 1 | 2021-03-02 10:24:24 | announced | |
2 | 2021-03-02 22:27:24 | announced | 2021-03-03: Updated publication reference for PubMed record(s): 33594975. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Neurodegeneration, Lysine acetylation, TRRAP, Wnt signalling, SP transcription factors |
Contact List
Zhao-Qi Wang |
contact affiliation | Leibniz Institute on Aging Fritz Lipmann Institute (FLI) Beutenbergstrasse 11 07745 Jena Germany |
contact email | Zhao-Qi.Wang@leibniz-fli.de |
lab head | |
Joanna Kirkpatrick |
contact affiliation | Leibniz Institute on Aging - FLI |
contact email | joanna.kirkpatrick@leibniz-fli.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD013730 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013730
- Label: PRIDE project
- Name: Trrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity