PXD013721-1
PXD013721 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development-2 |
| Description | The senescence-associated secretory phenotype (SASP) has recently emerged as both a driver of -- and promising therapeutic target for -- a multitude of chronic age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically monitored by the secretion of a few proteins, has been greatly underappreciated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present SASP Atlas, a comprehensive proteomic database of SASPs driven by multiple inducers of senescence in different human cell types. While there are common elements among all the SASPs we have documented so far, we discovered distinct senescence inducer- and cell type-specific secretory proteins. In all cases, the SASPs are comprised of hundreds of unique proteins secreted as both soluble proteins (sSASP) and exosomes (eSASP) with distinct and novel protein profiles. This resource will aid in identifying the proteins that drive senescence-associated phenotypes and provide comprehensive catalogs of potential senescence biomarkers that can be used to assess the burden and the originating stimuli and type of senescent cells in vivo. |
| HostingRepository | MassIVE |
| AnnounceDate | 2019-05-06 |
| AnnouncementXML | Submission_2019-05-06_16:56:13.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nate |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Carbamidomethyl |
| Instrument | TripleTOF 5600; TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-05-06 13:34:56 | ID requested | |
| ⏵ 1 | 2019-05-06 16:56:13 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: senescence, data-independent acquisition, secretome, sasp, senescence-associated secretory phenotype, aging, biomarker |
Contact List
| Birgit Schilling | |
|---|---|
| contact affiliation | The Buck Institute for Research on Aging |
| contact email | bschilling@buckinstitute.org |
| lab head | |
| Nate | |
| contact affiliation | The Buck Institute for Research on Aging |
| contact email | nbasisty@buckinstitute.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083750 |
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