PXD013689-2

PXD013689 is an original dataset announced via ProteomeXchange.

Title	Brain adiponectin signaling controls peripheral insulin response in Drosophila
Description	The brain plays a key role in energy homeostasis, detecting circulating hormones from peripheral organs, nutrients, and metabolites, and integrating this information to control food intake and energy expenditure. However, the signals mediating communication between peripheral organs and brain are largely unknown. Here, we show that a group of neurons in the Drosophila larval brain expressing the adiponectin receptor (AdipoR) control systemic growth and metabolism. We identify glucose-regulated protein 78 (Grp78) as a circulating ligand for AdipoR. Grp78 is produced by fat cells in response to dietary sugar and modulates the activity of AdipoR-positive neurons. The terpenoid juvenile hormone (JH) serves as an effector for brain AdipoR signaling, reducing the levels of insulin signaling in peripheral organs. In conclusion, we identify a neuroendocrine axis whereby AdipoR neurons control systemic insulin responses by modulating peripheral JH function.
HostingRepository	PRIDE
AnnounceDate	2021-06-17
AnnouncementXML	Submission_2021-06-16_22:59:04.504.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lauriane Kuhn
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-02 01:33:27	ID requested
1	2021-06-15 08:12:34	announced
⏵ 2	2021-06-16 22:59:04	announced	2021-06-17: Updated project metadata.
3	2024-10-22 05:23:00	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Insulin response, energy homeostasis, growth, Juvenile Hormone, Drosophila, Adiponectin receptor

Nathalie ARQUIER
contact affiliation	Aix-Marseille University, INSERM, TAGC, UMR_S1090, Marseille, France
contact email	nathalie.arquier@univ-amu.fr
lab head
Lauriane Kuhn
contact affiliation	CNRS, IBMC, FRC1589
contact email	l.kuhn@ibmc-cnrs.unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD013689

PRIDE project URI

• PRIDE
  1. PXD013689
     1. Label: PRIDE project
     2. Name: Brain adiponectin signaling controls peripheral insulin response in Drosophila