PXD013647 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 1) |
Description | Epithelial tissues are highly organized structures that rely on cell polarity pathways driven by membrane receptors and scaffolding proteins. SCRIBBLE is a cytoplasmic scaffold present at cell-cell junctions in polarized cells that contains LRR and PDZ domains as its paralogue LANO, a member of the LAP protein family. The family is composed of DENSIN-180, ERBIN, SCRIB and LRRC1. Based on phylogenic tree, LAP proteins can be split in two branches with the first branch is made up with SCRIB and LRCC1 and the second one of ERBIN and DENSIN-180. The current interactome of SCRIB and LRRC1 consists of 67 and 30 protein interaction partners respectively with only 9 (10%) common partners (BioGRID, version 3.5). Our study uncovers the proteome associated to SCRIB and LRRC1 and described for the first time protein associated to each paralogue. |
HostingRepository | PRIDE |
AnnounceDate | 2019-09-25 |
AnnouncementXML | Submission_2019-09-25_09:56:13.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Luc Camoin |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-04-26 03:29:39 | ID requested | |
⏵ 1 | 2019-09-25 09:56:14 | announced | |
Publication List
Daulat AM, Wagner MS, Walton A, Baudelet E, Audebert S, Camoin L, Borg JP, -Catenin Signaling Pathway. Proteomics, 19(21-22):e1800487(2019) [pubmed] |
Keyword List
submitter keyword: SCRIB |
LRRC1 |
proteomics analysis |
Contact List
Luc Camoin |
contact affiliation | Inserm, CBRS, Ais Marseille University, CRCM, Marseille Proteomics |
contact email | luc.camoin@inserm.fr |
lab head | |
Luc Camoin |
contact affiliation | Life Sciences |
contact email | luc.camoin@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD013647 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013647
- Label: PRIDE project
- Name: The tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 1)