PXD013639-1

PXD013639 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages
Description	Decline in tissue NAD levels during aging has been linked to aging-associated diseases, such as age-related metabolic disease, physical decline, and Alzheimers disease. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1 macrophages, but not naive or M2 macrophages, highly express the NAD consuming enzyme CD38 and have enhanced CD38-dependent NADase activity. Furthermore, we show that aging is associated with enhanced inflammation due to increased senescent cells, and the accumulation of CD38 positive M1 macrophages in visceral white adipose tissue. We also find that inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induces macrophages to proliferate and express CD38. As senescent cells progressively accumulate in adipose tissue during aging, these results highlight a new causal link between visceral tissue senescence and tissue NAD decline during aging and may present a novel therapeutic opportunity to maintain NAD levels during aging.
HostingRepository	MassIVE
AnnounceDate	2019-04-25
AnnouncementXML	Submission_2019-04-25_13:51:42.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nate
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Carbamidomethyl; Oxidation
Instrument	TripleTOF 6600; TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-25 13:35:13	ID requested
⏵ 1	2019-04-25 13:51:43	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: aging, cd38, macrophages, NAD, senescence, secretome

submitter keyword: aging, cd38, macrophages, NAD, senescence, secretome

Contact List

Birgit Schilling
contact affiliation	Buck Institute for Research on Aging
contact email	bschilling@buckinstitute.org
lab head
Nate
contact affiliation	The Buck Institute for Research on Aging
contact email	nbasisty@buckinstitute.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083726