PXD013573 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A core proliferative program induced by B-cell receptor stimulation in chronic lymphocytic leukemia cells |
Description | The B-cell receptor (BCR) signaling is crucial for the pathophysiology of chronic lymphocytic leukemia (CLL). Although the BCR has recently emerged as a new therapeutic target the precise mechanisms by which BCR signaling controls neoplastic B-cell proliferation are still ill characterized. Here, by comparing proliferating vs. non-proliferating cells from aggressive CLL patients, we longitudinally characterized the transcriptional and proteomic response of CLL cells after BCR engagement ex vivo. Of the 5,733 genes and/or proteins which expression was modulated after BCR activation, we identified a CLL proliferative signature including 430 genes and 374 proteins. Mathematical modelling of this signature revealed a nested sub-regulatory network comprising transcription factors activated within hours after cell activation linked to proteins involved in cell proliferation days after stimulation. The mining of this core cellular program sustaining primary human cancer cells proliferation provides an evidence based-resource for innovative therapeutic perspectives. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-29 |
AnnouncementXML | Submission_2021-03-29_07:53:06.912.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Leslie MULLER |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-04-18 08:28:50 | ID requested | |
⏵ 1 | 2021-03-29 07:53:07 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Leukemogenesis, B-cell receptor (BCR), lymphoproliferation, chronic lymphocytic leukemia (CLL), transcriptome and proteome, temporal response, mathematical modelling, machine learning, biological network reverse-engineering, cellular program. |
Contact List
Sarah CIANFERANI |
contact affiliation | Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France |
contact email | sarah.cianferani@unistra.fr |
lab head | |
Leslie MULLER |
contact affiliation | UMR7178 IPHC-DSA-LSMBO |
contact email | leslie.muller@etu.unistra.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD013573 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013573
- Label: PRIDE project
- Name: A core proliferative program induced by B-cell receptor stimulation in chronic lymphocytic leukemia cells