PXD013497 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The secretome of cultured human endothelial cells in modelled microgravity |
| Description | Using chromatography-mass spectrometry on an Ultimate 3000 chromatograph combined with a Maxis 4G mass spectrometer, the secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and modeling microgravity for 24 hours was studied. In the secretome of cells under microgravity conditions, a group of microtubule proteins was identified, among which many structural elements of microtubules, as well as regulatory proteins interacting with Rho-GTPases. Thus, the reorganization of actin cytoskeleton and microtubules caused by microgravity is under a complex regulation mediated by Rho proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-01 |
| AnnouncementXML | Submission_2026-07-01_02:46:11.788.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Alexander Brzhozovskiy |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
| Instrument | LTQ FT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2019-04-15 01:50:01 | ID requested | |
| ⏵ 1 | 2026-07-01 02:46:12 | announced | |
Publication List
| 10.1007/s10517-019-04454-8; |
| Kashirina DN, Kononikhin AS, Larina IM, Buravkova LB, Secretome of Cultured Human Endothelial Cells in Simulated Microgravity. Bull Exp Biol Med, 167(1):35-38(2019) [pubmed] |
Keyword List
| submitter keyword: endothelial cells, microtubules, Rho-GTPases, secretome, chromatography-mass spectrometry |
Contact List
| Irina Larina |
|---|
| contact affiliation | IBP RAS |
| contact email | irina.larina@gmail.com |
| lab head | |
| Alexander Brzhozovskiy |
|---|
| contact affiliation | V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology,
Ministry of Healthcare of the Russian Federation, Moscow, Russia |
| contact email | agb.imbp@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD013497 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013497
- Label: PRIDE project
- Name: The secretome of cultured human endothelial cells in modelled microgravity
