PXD013225-2

PXD013225 is an original dataset announced via ProteomeXchange.

Title	RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.
Description	The human opportunistic pathogen Staphylococcus aureus has developed multiple strategies to adapt to various environments, to fight and escape the immune system, to spread and persist in host tissues. It is responsible for numerous diseases ranging from benign skin infections to more serious such as endocarditis or septicemia. The pathogenicity is due to the production of a multitude of virulence factors, whose synthesis is finely regulated by a combination of regulatory proteins and small non-coding RNAs (sRNAs). Our study reveals an unexpected function of an atypical sRNA, RsaC, which is at the heart of networks controlling defence responses to oxidative stress, manganese import and nutrition immunity. This work highlights a novel mechanism required for S. aureus to survive into its host.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:03:18.751.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johana Chicher
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-25 07:20:55	ID requested
1	2019-11-11 15:32:56	announced
⏵ 2	2024-10-22 04:03:26	announced	2024-10-22: Updated project metadata.

10.1093/nar/gkz728;

Lalaouna D, Baude J, Wu Z, Tomasini A, Chicher J, Marzi S, Vandenesch F, Romby P, Caldelari I, Moreau K, RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation. Nucleic Acids Res, 47(18):9871-9887(2019) [pubmed]

submitter keyword: reuglatory RNA, nutritional immunity, Staphylococcus aureus, oxidative stress

David Lalaouna
contact affiliation	Université de Strasbourg, CNRS, Architecture et Réactivité de l’ARN, UPR9002, Strasbourg, France
contact email	d.lalaouna@ibmc-cnrs.unistra.fr
lab head
Johana Chicher
contact affiliation	Université de Strasbourg, Plateforme Protéomique Strasbourg-Esplanade, Centre National de la Recherche Scientifique
contact email	j.chicher@ibmc-cnrs.unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD013225

PRIDE project URI

• PRIDE
  1. PXD013225
     1. Label: PRIDE project
     2. Name: RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.