PXD012982-1

PXD012982 is an original dataset announced via ProteomeXchange.

Title	Identification of the early exoproteome of pathogenic Aspergilli, Aspergillus flavus and Aspergillus fumigatus
Description	We identified the proteins secreted by A. flavus and A. fumigatus conidia during the early stages of growth. A comparative analysis was done between the exoproteome of the two species to identify the core proteins that were common between the two Aspergilli as well as species specific signature protiens. The common proteins included cell wall polysaccharide modifying enzymes and those required for nutrient acquisition. The core proteome is an indication that A. flavus and A. fumigatus share the common events during germination and growth. On the other hand, each Aspergillus had a unique subset of proteins that could be potential virulence factors or effector molecules. This species-specific exoprotein signature probably reflects the specific requirements of the Aspergillus pathogen to establish an infection in a particular niche.
HostingRepository	PRIDE
AnnounceDate	2025-01-17
AnnouncementXML	Submission_2025-01-16_22:55:36.824.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012982
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jeya Maheshwari Jayapal
SpeciesList	scientific name: Aspergillus fumigatus Af293; NCBI TaxID: 330879; scientific name: Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167); NCBI TaxID: 332952;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-05 08:26:05	ID requested
⏵ 1	2025-01-16 22:55:37	announced

Venugopalan LP, Aimanianda V, Namperumalsamy VP, Prajna L, Kuppamuthu D, Jayapal JM, Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens. Appl Microbiol Biotechnol, 107(12):4025-4040(2023) [pubmed]

10.1007/s00253-023-12559-4;

10.6019/PXD012982;

submitter keyword: conidia, A. flavus, A. fumigatus,exoproteome

Dharmalingam Kuppamuthu
contact affiliation	Department of Proteomics Aravind Medical Research Foundation Madurai
contact email	dharmalingam.k@gmail.com
lab head
Jeya Maheshwari Jayapal
contact affiliation	Aravind Medical Research Foundation
contact email	jm.jeya@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD012982

PRIDE project URI

• PRIDE
  1. PXD012982
     1. Label: PRIDE project
     2. Name: Identification of the early exoproteome of pathogenic Aspergilli, Aspergillus flavus and Aspergillus fumigatus