PXD012540-3
PXD012540 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HDAC2 regulates site-specific acetylation of MDM2 and its ubiquitination signaling in tumor suppression |
| Description | Histone deacetylases (HDACs) are promising targets for cancer therapy, while their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in regulation of MDM2 acetylation at previously uncharacterized lysines. Upon inactivation of HDAC2, this acetylation creates a structural signal in the lysine-rich domain of MDM2 to prevent the recognition and degradation of its downstream substrate, MCL-1 Ubiquitin Ligase E3 (MULE). This mechanism further reveals a therapeutic connection between the MULE ubiquitin ligase function and tumor suppression. Specifically, we show that HDAC inhibitor treatment promotes the accumulation of MULE, which diminishes the t(X;18) translocation-associated synovial sarcomagenesis by directly targeting the fusion product SS18-SSX for degradation. These results uncover a new HDAC2-dependent pathway that integrates reversible acetylation signaling to the anticancer ubiquitin response. |
| HostingRepository | jPOST |
| AnnounceDate | 2020-03-22 |
| AnnouncementXML | Submission_2022-09-18_02:15:40.487.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kumiko Shiozawa |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxymethyl-L-cysteine; N6-acetyl-L-lysine; L-methionine sulfoxide |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-01-28 19:29:06 | ID requested | |
| 1 | 2020-03-21 08:00:06 | announced | |
| 2 | 2021-02-04 17:17:28 | announced | 2021-02-04: Updated FTP location. |
| ⏵ 3 | 2022-09-18 02:15:40 | announced | 2022-09-18: Updated FTP location. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: FK228-treated endogeneous MDM2 IP |
Contact List
| Le Su | |
|---|---|
| lab head | |
| Kumiko Shiozawa | |
| contact affiliation | National Cancer Centre |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000550/ |
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