PXD012525 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Schistosomes- exosomal miRNAs: modulators of T helper (CD+) cell differentiation |
Description | Schistosomiasis (Bilharziasis) is caused by the helminth Schistosoma. The acute stage of the infection extends from the penetration of the parasite through the host skin until it reaches its final location as adult female and male in copula, at the blood vessels around the gut or bladder. The female starts then depositing fertile eggs. The chronic stage of schistosomiasis starts with laying the eggs which promote a strong immunological Th2 response. It is unclear, so far, how this Th2 response gradually declines even though the parasitic worms live for years and continue to produce eggs. Here we demonstrate that schistosomes downregulate the differentiation toward the Th2 lineage by modulating the Th2 transcriptional program. Moreover, we found that adult schistosomes secrete micro-vesicles, possessing exosomal characteristics, and containing miRNAs, which have been found in Th2 cells that exposed indirectly to schistosomes. Importantly, we demonstrate that, the schistosoma miR-10 molecule targets MAP3K7, which consequently down modulates NF-kB. Since NF-kB is a critical factor necessary for Th2 differentiation and function, our results can at least partially explain, the decrease of the Th2 response over time of infection This exosomal worm-host immune cell interaction, can be further utilized for the development of novel diagnostic and therapeutic approaches to schistosomiasis. |
HostingRepository | PRIDE |
AnnounceDate | 2019-12-10 |
AnnouncementXML | Submission_2020-01-15_03:49:23.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tamar Ziv |
SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-01-28 01:22:33 | ID requested | |
1 | 2019-12-10 02:31:22 | announced | |
⏵ 2 | 2020-01-15 03:49:25 | announced | 2020-01-15: Updated publication reference for PubMed record(s): 31825165. |
Publication List
Meningher T, Barsheshet Y, Ofir-Birin Y, Gold D, Brant B, Dekel E, Sidi Y, Schwartz E, Regev-Rudzki N, Avni O, Avni D, Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation. EMBO Rep, 21(1):e47882(2020) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Schistosomes, T helper, miRNA |
Contact List
Dror Avni |
contact affiliation | Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Medicine C, Molecular Laboratory for the Study of Tropical Diseases,Sheba Medical Center, Tel Hashomer. |
contact email | droravni@msn.com |
lab head | |
Tamar Ziv |
contact affiliation | Technion |
contact email | tamarz@tx.technion.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012525
- Label: PRIDE project
- Name: Schistosomes- exosomal miRNAs: modulators of T helper (CD+) cell differentiation