PXD012277-3

PXD012277 is an original dataset announced via ProteomeXchange.

Title	Proteome of HEK293T cells upon P2YR6 overexpression
Description	Defense against virus infections relies on rapid and massive engagement of cellular proteins with antiviral properties. Germline-encoded pattern recognition receptors (PRRs) sense the presence of pathogens and initiate a signaling cascade leading to the induction of antiviral cytokines, including type-I interferons. IFN-alpha/beta bind to the IFN receptor (IFNAR), initiating signaling that culminates in the expression of interferon-stimulated genes (ISGs). In sum, viral infection triggers the expression of several hundred proteins covering a wide range of biological activities. Among these proteins are PRRs (e.g. RIG-I, MDA5, TLRs), signaling molecules (e.g. MYD88, MAVS), transcription factors (e.g. IRFs, STATs) and proteins with direct antiviral functions (e.g. MX proteins, IFITs), as well as negative regulators of immune responses (e.g. SOCS proteins, DAPK1) that prevent overshooting of immune reactions. ISGs are thus a heterogeneous group of proteins that serve different purposes related to direct antiviral defense and immune regulation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:46:26.410.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pietro Scaturro
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-01-09 01:50:28	ID requested
1	2019-03-01 10:12:32	announced
2	2019-04-03 06:43:07	announced	Updated publication reference for PubMed record(s): 30833792.
⏵ 3	2024-10-22 04:46:34	announced	2024-10-22: Updated project metadata.

10.1038/s41590-019-0323-3;

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A, A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol, 20(4):493-502(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: P2YR6, Label-free quantification, LFQ, QExactive

Andreas Pichlmair
contact affiliation	Institute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich
contact email	andreas.pichlmair@tum.de
lab head
Pietro Scaturro
contact affiliation	Systems Arbovirology, Leibniz Institute of Virology
contact email	pietro.scaturro@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012277

PRIDE project URI

• PRIDE
  1. PXD012277
     1. Label: PRIDE project
     2. Name: Proteome of HEK293T cells upon P2YR6 overexpression