PXD012220 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effects of CerS4 deletion in murine epidermis on proteome and lipidome |
Description | Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from Ctr and CerS4epi-/- at different ages (P21, P33, P47) were compared, to identify the effect of CerS4 on barrier maintenance. |
HostingRepository | PRIDE |
AnnounceDate | 2020-02-27 |
AnnouncementXML | Submission_2020-02-27_05:51:49.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Frederik Tellkamp |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-01-02 07:28:03 | ID requested | |
⏵ 1 | 2020-02-27 05:51:51 | announced | |
2 | 2024-10-22 04:52:09 | announced | 2024-10-22: Updated project metadata. |
Publication List
Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Uterm, ö, hlen O, Kr, ö, nke M, Niessen CM, Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis. J Invest Dermatol, 140(10):1927-1937.e5(2020) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: CerS4, epidermal barrier, Ceramides, lipid homeostasis, barrier formation, barrier maintenance |
Contact List
Carien M. Niessen |
contact affiliation | Department of Dermatology, University of Cologne, Cologne |
contact email | ait91@uni-koeln.de |
lab head | |
Frederik Tellkamp |
contact affiliation | University of Cologne |
contact email | ftellka1@uni-koeln.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD012220 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012220
- Label: PRIDE project
- Name: Effects of CerS4 deletion in murine epidermis on proteome and lipidome