PXD012154-2

PXD012154 is an original dataset announced via ProteomeXchange.

Title	Coxsackievirus B persistence modifies the secretome of pancreatic ductal cells in a virus-strain-specific manner, part 2
Description	The group B Coxsackieviruses can establish persistent infections in human cells, and these infections have been linked to chronic diseases including type 1 diabetes. Still, only little is known about persistent Coxsackievirus B infection induced changes in human pancreas. We have established persistent Coxsackievirus B1 infections in human pancreatic duct cell line using two different virus strains, and studied infection-induced changes in protein secretion using mass spectrometry-based proteomics. Persistent Coxsackievirus B1 infections caused broad changes in protein secretion, for example changes regulated secretory pathway. Strikingly, many changes differed between the virus strains, including extensive shut down of antiviral immune responses by one of the viruses. Our results provide novel information about persistent Coxsackievirus B infection induced changes in human pancreas and about the potential heterogeneity in the outcomes of the infections.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:51:35.208.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Niina Lietzen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-21 05:29:04	ID requested
1	2019-08-06 02:21:19	announced
⏵ 2	2024-10-22 04:51:35	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: pancreas,enterovirus, secretome, persistent infection

Riitta Lahesmaa
contact affiliation	Turku Centre for Biotechnology University of Turku and Åbo Akademi University Finland
contact email	riitta.lahesmaa@utu.fi
lab head
Niina Lietzen
contact affiliation	University of Turku
contact email	niina.lietzen@utu.fi
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD012154
     1. Label: PRIDE project
     2. Name: Coxsackievirus B persistence modifies the secretome of pancreatic ductal cells in a virus-strain-specific manner, part 2