PXD012131-1

PXD012131 is an original dataset announced via ProteomeXchange.

Title	Proteomic Atlas of the Human Brain in Alzheimer’s Disease
Description	Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small variance in expression, accompanied by a group of proteins that are highly differentially expressed in individual sections and broader regions. AD affected tissue exhibited slightly elevated levels of tau protein with similar relative expression to factors associated with the AD pathology. Substantial differences were identified between previous proteomic studies of mature adult brains and our aged cohort. Our findings suggest considerable value in examining specifically the brain proteome of aged human populations, with the goal of understanding ways in which neurological changes occur past full maturity. This resource can serve as a guide, as well as a point of reference for how specific regions of the brain are affected by aging.
HostingRepository	PRIDE
AnnounceDate	2020-01-09
AnnouncementXML	Submission_2020-01-09_14:14:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Justin McKetney
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-12-20 00:19:26	ID requested
⏵ 1	2020-01-09 14:14:17	announced
2	2024-10-22 04:51:27	announced	2024-10-22: Updated project metadata.

McKetney J, Runde RM, Hebert AS, Salamat S, Roy S, Coon JJ, Proteomic Atlas of the Human Brain in Alzheimer's Disease. J Proteome Res, 18(3):1380-1391(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: human, brain, Alzheimer's, neurodegeneration

Joshua J Coon
contact affiliation	Department of Chemistry and Biomolecular Chemistry, University of Wisconsin, Wisconsin, USA
contact email	jcoon@chem.wisc.edu
lab head
Justin McKetney
contact affiliation	University of Wisconsin - Madison
contact email	mcketney@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD012131

PRIDE project URI

• PRIDE
  1. PXD012131
     1. Label: PRIDE project
     2. Name: Proteomic Atlas of the Human Brain in Alzheimer’s Disease