PXD011859-3

PXD011859 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial mutant Caenorhabditis elegans phosphoproteome
Description	Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the phosphoproteomic landscape of Caenorhabditis elegans with severe mitochondrial deficiency in the context of insulin signaling inhibition.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:50:49.508.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antonia Piazzesi
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-11-28 00:33:06	ID requested
1	2019-02-13 04:02:58	announced
2	2019-05-27 01:45:57	announced	Updated publication reference for PubMed record(s): 30796049.
⏵ 3	2024-10-22 04:50:57	announced	2024-10-22: Updated project metadata.

Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, Bano D, dysfunction. EMBO J, 38(6):(2019) [pubmed]

10.15252/embj.201899558;

curator keyword: Biological

submitter keyword: metabolism,Caenorhabditis elegans, insulin signaling, Complex I, mitochondria, mitochondrial deficiency, IIS

Daniele Bano
contact affiliation	DZNE, Bonn, Germany
contact email	Daniele.Bano@dzne.de
lab head
Antonia Piazzesi
contact affiliation	DZNE
contact email	Antonia.Piazzesi@dzne.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011859

PRIDE project URI

• PRIDE
  1. PXD011859
     1. Label: PRIDE project
     2. Name: Mitochondrial mutant Caenorhabditis elegans phosphoproteome