PXD011753 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hfq is involved in global protein expression and stress response in Bordetella pertussis |
Description | In this study, we used gel-free nanoLC-MS/MS-based proteomics to compare the protein profile of B. pertussis wild type and an isogenic hfq defective mutant strain under control an iron limited conditions. We found that Hfq affects the abundance of 302 proteins, which represents 8% of the total B. pertussis coding sequence. The absence of Hfq induced changes in the abundance of proteins involved in metabolic pathways, stress response and virulence. Hfq was also found involved in B. pertussis adaptation to iron starvation, one of the main stresses this pathogen faces inside the host. Altogether, these results indicate that B. pertussis Hfq is involved in bacterial physiological processes as well as bacterial pathogenesis. |
HostingRepository | PRIDE |
AnnounceDate | 2020-02-18 |
AnnouncementXML | Submission_2020-02-18_07:53:17.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kristin Surmann |
SpeciesList | scientific name: Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251); NCBI TaxID: 257313; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-11-20 01:24:33 | ID requested | |
⏵ 1 | 2020-02-18 07:53:18 | announced | |
Publication List
Alvarez Hayes J, Surmann K, Lamberti Y, Depke M, Dhople V, Blanc, á B, Ruiz E, Vecerek B, Schmidt F, V, ö, lker U, Rodriguez ME, Hfq modulates global protein pattern and stress response in Bordetella pertussis. J Proteomics, 211():103559(2020) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: B. pertussis, Hfq, iron limitation, proteomics, stress response |
Contact List
Prof. Uwe Völker |
contact affiliation | Department of Functional Genomics, Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany |
contact email | voelker@uni-greifswald.de |
lab head | |
Kristin Surmann |
contact affiliation | University Medicine Greifswald |
contact email | surmannk@uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD011753 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011753
- Label: PRIDE project
- Name: Hfq is involved in global protein expression and stress response in Bordetella pertussis