PXD011536-2

PXD011536 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of liver tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)
Description	To evaluate functional consequences of insulin-deficient diabetes mellitus for the liver, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Liver samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal pathways and key drivers significantly affected by chronic insulin deficiency and hyperglycemia.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:49:58.394.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Florian Flenkenthaler
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-31 07:23:18	ID requested
1	2019-11-12 15:24:58	announced
⏵ 2	2024-10-22 04:50:01	announced	2024-10-22: Updated project metadata.

10.1016/j.molmet.2019.05.011;

Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, L, ä, ndstr, ö, m E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fr, ö, hlich T, Arnold GJ, Blum H, Wolf E, Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus. Mol Metab, 26():30-44(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Animal model, Biobank, MIDY, Pig model,Diabetes, Liver, LC-MS/MS

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	frohlich@genzentrum.lmu.de
lab head
Florian Flenkenthaler
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	flenkenthaler@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD011536

PRIDE project URI

• PRIDE
  1. PXD011536
     1. Label: PRIDE project
     2. Name: Proteomic analysis of liver tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)