PXD011453 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Kidney proteomics in the folic acid (FA) induced nephropathy mouse model |
Description | Treatments for kidney fibrosis represent an urgent yet unmet clinical need. Effective therapies are limited due to not well understood molecular pathogenesis. We aimed at generating a comprehensive and integrated multi-omics data set (RNA/ microRNA transcriptomics and proteomics) of fibrotic kidneys which will be searchable through a user-friendly web application. Therefore, two commonly used mouse models were utilized: a reversible chemical-induced injury model (folic acid (FA) induced nephropathy) and an irreversible surgical-induced fibrosis model (unilateral ureteral obstruction (UUO)). RNA and small RNA sequencing as well as MS/MS with 10-plex tandem mass tags proteomics were performed with kidney samples from different time points over the course of fibrosis development. In summary, we present temporal and integrated multi-omics data from fibrotic mouse kidneys which are accessible through an interrogation tool to provide a searchable transcriptome and proteome for kidney fibrosis researcher. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:49:49.512.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Matthew Berberich |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-10-23 01:52:08 | ID requested | |
1 | 2019-05-09 00:20:18 | announced | |
2 | 2019-06-19 01:31:36 | announced | Updated publication reference for PubMed record(s): 31201317. |
⏵ 3 | 2024-10-22 04:49:50 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s41597-019-0095-5; |
Pavkovic M, Pantano L, Gerlach CV, Brutus S, Boswell SA, Everley RA, Shah JV, Sui SH, Vaidya VS, Multi omics analysis of fibrotic kidneys in two mouse models. Sci Data, 6(1):92(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: CKD, fibrosis, mouse,Kidney |
Contact List
Vishal S. Vaidya, Ph.D. |
contact affiliation | Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA Department of Medicine – Renal Division, Brigham and Women’s Hospital, Boston, MA |
contact email | vvaidya@bwh.harvard.edu |
lab head | |
Matthew Berberich |
contact affiliation | Center for Protein Degradation/Dana-Farber Cancer Institute |
contact email | matthew_berberich@dfci.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011453
- Label: PRIDE project
- Name: Kidney proteomics in the folic acid (FA) induced nephropathy mouse model