PXD011428-2

PXD011428 is an original dataset announced via ProteomeXchange.

Title	Mouse brain proteome map of Experimental autoimmune encephalomyelitis (EAE) mouse model
Description	Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS); its cause is unknown. To understand the pathogenesis of MS, researchers often use the experimental autoimmune encephalomyelitis (EAE) mouse model. Here, our aim was to build a proteome map of the biological changes that occur during MS at the major onset sites—the brain and the spinal cord. We performed quantitative proteome profiling in five specific brain regions and the spinal cord of EAE and healthy mice with high-resolution mass spectrometry based on tandem mass tags.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:49:45.208.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dohyun Han
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-19 08:52:56	ID requested
1	2019-02-25 04:07:30	announced
⏵ 2	2024-10-22 04:49:46	announced	2024-10-22: Updated project metadata.

10.1002/pmic.201800355;

Hasan M, Min H, Rahaman KA, Muresan AR, Kim H, Han D, Kwon OS, Quantitative Proteome Analysis of Brain Subregions and Spinal Cord from Experimental Autoimmune Encephalomyelitis Mice by TMT-Based Mass Spectrometry. Proteomics, 19(5):e1800355(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Mouse, Brain, TMT, EAE, quantitative proteomics

Dohyun Han
contact affiliation	Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital
contact email	hdh03@snu.ac.kr
lab head
Dohyun Han
contact affiliation	Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital
contact email	hdh03@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011428

PRIDE project URI

• PRIDE
  1. PXD011428
     1. Label: PRIDE project
     2. Name: Mouse brain proteome map of Experimental autoimmune encephalomyelitis (EAE) mouse model