PXD011386-2

PXD011386 is an original dataset announced via ProteomeXchange.

Title	Quantifying changes in the bacterial thiol redox proteome during host-pathogen interaction
Description	In this study, we used a quantitative redox proteomic method (OxICAT) to assess the in vivo thiol oxidation status of phagocytized E. coli. The majority (65.5%) of identified proteins harbored thiols that were significantly oxidized (>30%) upon phagocytosis. A substantial number of these proteins are from major metabolic pathways or are involved in cell detoxification and stress response, suggesting a systemic breakdown of the bacterial cysteine proteome in phagocytized bacteria.
HostingRepository	PRIDE
AnnounceDate	2019-01-07
AnnouncementXML	Submission_2019-02-11_04:29:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lars Leichert
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	Applied Biosystems cleavable ICAT(TM) heavy; Applied Biosystems cleavable ICAT(TM) light
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-10-17 05:05:27	ID requested
1	2019-01-07 09:40:30	announced
⏵ 2	2019-02-11 04:29:19	announced	Updated publication reference for PubMed record(s): 30682706.
3	2024-10-22 04:49:43	announced	2024-10-22: Updated project metadata.

Xie K, Bunse C, Marcus K, Leichert LI, Quantifying changes in the bacterial thiol redox proteome during host-pathogen interaction. Redox Biol, 21():101087(2019) [pubmed]

curator keyword: Biological

submitter keyword: Escherichia coli, PLB-985, Neutrophils, Redox proteomics

Lars I. Leichert
contact affiliation	Ruhr-Universität Bochum Institute for Biochemistry and Pathobiochemistry Microbial Biochemistry Universitätsstrasse 150 44780 Bochum Germany
contact email	lars.leichert@ruhr-uni-bochum.de
lab head
Lars Leichert
contact affiliation	Ruhr-Universität Bochum
contact email	lars.leichert@ruhr-uni-bochum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD011386

PRIDE project URI

• PRIDE
  1. PXD011386
     1. Label: PRIDE project
     2. Name: Quantifying changes in the bacterial thiol redox proteome during host-pathogen interaction