PXD011352-4
PXD011352 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients |
| Description | We performed proteomic profiling on serum samples from paired pre- and post-operative CRC patients, colorectal polyps patients and healthy controls using an approach combining magnetic bead-based weak cation exchange and matrix-assisted laser desorption ionization-time of flight mass spectrometry. We next performed liquid chromatography-electrospray ionization-tandem mass spectrometry to identify the proteins and selected potential biomarker based on bioinformatics analysis of the TCGA and GEO dataset. 5 peptides showing the most significant changes in abundance across paired pre- and post-operation CRC patients, colorectal polyps patients and healthy controls were identified as peptide regions of FGA, MUC5AC and SETD7. Bioinformatics analysis suggested that the up-regulation of SETD7 in CRC is relatively specific. Validation studies showed that SETD7 expression increased from healthy controls to those with colorectal polyps and finally CRC patients, and decreased following surgery. |
| HostingRepository | iProX |
| AnnounceDate | 2019-04-17 |
| AnnouncementXML | Submission_2019-04-25_22:44:00.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Baojun Duan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2018-10-14 18:21:05 | ID requested | |
| 1 | 2018-10-14 18:34:59 | announced | |
| 2 | 2018-10-15 23:17:58 | announced | Update description information. |
| 3 | 2018-10-16 23:34:39 | announced | Update description information. |
| ⏵ 4 | 2019-04-25 22:44:01 | announced | Update description information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colorectal cancer, Proteomics, Serum biomarker, SETD7 |
Contact List
| Chen Huang | |
|---|---|
| contact affiliation | Xi'an Jiaotong University |
| contact email | hchen@mail.xjtu.edu.cn |
| lab head | |
| Baojun Duan | |
| contact affiliation | Xi'an Jiaotong University, Shaanxi Provincial People's Hospital |
| contact email | duanbaojun.cn@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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