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PXD011322-1

PXD011322 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKRAB Zincfinger Interactome
DescriptionKrüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) represent the largest family of human transcription factors. The majority of its members bind to Transposable Elements (TEs), which they repress through the recruitment of the repressor KAP1 to their conserved KRAB domain. In addition to this recognized role, some KZFPs seem to favor different types of loci such as transcription start sites or display diverse functions such as imprinting and gene regulation. Intriguingly, a subset of KZFPs was shown not to recruit the corepressor KAP1. Therefore, we sought to get a better picture of KZFPs putative roles and their association with KAP1. In order to do so, we generated the interactomes of 101 KZFPs through Affinity Purification followed by Mass Spectrometry (AP-MS).
HostingRepositoryPRIDE
AnnounceDate2019-06-04
AnnouncementXMLSubmission_2019-06-04_04:17:11.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMoritz Heusel
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-10-10 00:25:45ID requested
12019-06-04 04:17:12announced
22019-08-19 07:06:43announcedUpdated publication reference for PubMed record(s): 31403225.
32024-10-22 04:49:22announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: KRAB, Zincfinger, AP-MS, Mass Spectrometry
Contact List
Rudolf Aebersold
contact affiliationInstitute of Molecular Systems Biology, ETH Zurich Faculty of Science, University of Zurich
contact emailaebersold@imsb.biol.ethz.ch
lab head
Moritz Heusel
contact affiliationETHZ
contact emailheusel@imsb.biol.ethz.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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