PXD011309 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of potential plasma biomarkers for abdominal aortic aneurysm using tandem mass tag quantitative proteomics |
| Description | Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an ELISA assay. The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA. |
| HostingRepository | PRIDE |
| AnnounceDate | 2018-10-22 |
| AnnouncementXML | Submission_2018-10-22_06:04:17.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Egor Vorontsov |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2018-10-09 01:57:25 | ID requested | |
| ⏵ 1 | 2018-10-22 06:04:18 | announced | |
| 2 | 2024-10-22 04:49:34 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Henriksson AE, Lindqvist M, Sihlbom C, Bergstr, รถ, m J, Bylund D, Identification of Potential Plasma Biomarkers for Abdominal Aortic Aneurysm Using Tandem Mass Tag Quantitative Proteomics. Proteomes, 6(4):(2018) [pubmed] |
Keyword List
| submitter keyword: Plasma proteomics |
| immunodepletion |
| tandem mass tags |
| TMT |
| abdominal aortic aneurysm |
| cardiovascular diseases |
Contact List
| Anders E. Henriksson |
|---|
| contact affiliation | Professor, Department of Laboratory Medicine, Sundsvall County Hospital, Sundsvall, Sweden |
| contact email | anders.henriksson@rvn.se |
| lab head | |
| Egor Vorontsov |
|---|
| contact affiliation | Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden |
| contact email | yegor.msu@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011309
- Label: PRIDE project
- Name: Identification of potential plasma biomarkers for abdominal aortic aneurysm using tandem mass tag quantitative proteomics
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