PXD011159-2

PXD011159 is an original dataset announced via ProteomeXchange.

Title	Quantitative analysis of proteome dynamics in a long-term asthma mouse model
Description	Asthma bronchiale is an inflammatory disease of the respiratory airways and a major factor of increasing health care costs worldwide. The molecular actors leading to asthma are not fully understood and require further investigation. The aim of this study was to monitor the proteome during asthma development from early inflammatory to late fibrotic stages. A time-course-based ovalbumin (OVA) mouse model was applied to establish an asthma phenotype and the lung proteome was analysed at four time points during asthma development (0 weeks = control, 5 weeks, 8 weeks and 12 weeks of OVA treatment).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:18:51.763.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011159
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Thilo Bracht
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Propionamide; Oxidation; Carbamidomethyl; residues isobaric at 71.037114 Da
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-23 23:41:10	ID requested
1	2021-02-11 02:19:56	announced
⏵ 2	2024-10-22 05:18:52	announced	2024-10-22: Updated project metadata.

Funke L, Gnipp S, Ahrens M, Eisenacher M, Peters M, Sitek B, Bracht T, Quantitative analysis of proteome dynamics in a mouse model of asthma. Clin Exp Allergy, 51(11):1471-1481(2021) [pubmed]

10.1111/cea.13843;

10.6019/PXD011159;

submitter keyword: mouse model,Asthma bronchiale, time-course model, ovalbumin model

Barbara Sitek
contact affiliation	Ruhr Universität-Bochum Medizinisches Proteom-Center Clinical Proteomics Universitätsstraße 150 44801 Bochum Germany
contact email	barbara.sitek@rub.de
lab head
Thilo Bracht
contact affiliation	Clinical Proteomics
contact email	thilo.bracht@rub.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD011159

PRIDE project URI

• PRIDE
  1. PXD011159
     1. Label: PRIDE project
     2. Name: Quantitative analysis of proteome dynamics in a long-term asthma mouse model