PXD011142 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-Omics Analyses Revealed Conserved Aging Signatures in Mice |
Description | Studies on aging have largely included one or two OMICS layers, which may not necessarily reflect the signatures of other layers. Moreover, most aging studies have often compared very young (4-5 wks) mice with old (24 months) mice which does not reflect the aging transition after the attainment of adulthood. Therefore, we aimed to study and compared muti-OMICS aging signatures across key metabolic tissues of mature adults (6 months) and old (24 months) C57BL/6J mice (the most commonly used mouse strain). Here we compared the differentially regulated genes and enriched pathways for transcriptome, proteome and epigenome (H3K27ac, H3K4me3, H3K27me3, DNA methylation) across liver, heart, and quadriceps muscle. The major aging associated pathways cross multiple layers and tissues are decreased RNA metabolism, transcription, and translation at transcript and protein levels however increased potential of transcription at DNA methylation and H3K27ac levels. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-30 |
AnnouncementXML | Submission_2021-11-30_12:15:59.502.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Evan Williams |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-09-19 03:02:50 | ID requested | |
⏵ 1 | 2021-11-30 12:15:59 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: Mouse tissue aging |
Contact List
Ruedi Aebersold |
contact affiliation | Institue of Molecular Systems Biology ETH Zurich, Switzerland ( lab head ) (Alternate contact: Johan Auwerx, admin.auwerx@epfl.ch ; EPFL, Switzerland (lab head)) |
contact email | aebersold@imsb.ethz.ch |
lab head | |
Evan Williams |
contact affiliation | ETH Zurich |
contact email | evan.williams@uni.lu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD011142
- Label: PRIDE project
- Name: Multi-Omics Analyses Revealed Conserved Aging Signatures in Mice