PXD011095-3

PXD011095 is an original dataset announced via ProteomeXchange.

Title	Repression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling
Description	Cornerstones of the regulatory phenomena observed in hypoxic HPV-positive cancer cells are: (i) hypoxia blocks E6/E7, an effect that can be counteracted by (ii) AKT inhibition and by (iii) high glucose supply. To gain further insights into the underlying regulatory circuits, mass spectrometry-based quantitative proteome analyses were performed comparing normoxic and hypoxic SiHa cells and assessing their response towards AKTi VIII and 25 mM glucose under hypoxia
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:48:54.912.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bianca Kuhn
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-14 06:21:39	ID requested
1	2019-02-18 03:49:52	announced
2	2021-04-18 23:39:07	announced	2021-04-19: Updated project metadata.
⏵ 3	2024-10-22 04:49:01	announced	2024-10-22: Updated project metadata.

Bossler F, Kuhn BJ, G, ü, nther T, Kraemer SJ, Khalkar P, Adrian S, Lohrey C, Holzer A, Shimobayashi M, D, ü, rst M, Mayer A, R, ö, sl F, Grundhoff A, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F, Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling. mBio, 10(1):(2019) [pubmed]

10.1128/mbio.02323-18;

10.1002/ijc.33594;

Hoppe-Seyler K, Herrmann AL, D, ä, schle A, Kuhn BJ, Strobel TD, Lohrey C, Bulkescher J, Krijgsveld J, Hoppe-Seyler F, Effects of Metformin on the virus/host cell crosstalk in human papillomavirus-positive cancer cells. Int J Cancer, 149(5):1137-1149(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, HPV, TMT, quantitative Proteomics, Hypoxia

Felix Hoppe-Seyler
contact affiliation	Felix Hoppe-Seyler, Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany
contact email	hoppe-seyler@dkfz.de
lab head
Bianca Kuhn
contact affiliation	DKFZ Heidelbeg
contact email	bianca.kuhn@dkfz-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD011095

PRIDE project URI

• PRIDE
  1. PXD011095
     1. Label: PRIDE project
     2. Name: Repression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling