PXD011068-2

PXD011068 is an original dataset announced via ProteomeXchange.

Title	Proteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction
Description	This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil supplementation on the proteome profile of APP/PS1 mice hippocampus, medial prefrontal cortex, and striatum was also investigated. The analysis was performed using ultrahigh-performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry. This study was in hoped to understand the mechanisms of Alzheimer’s disease at proteome level, and pre-emptive activity of TRF to combat the disease.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:48:36.200.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hamizah Shahirah Hamezah
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-12 01:36:24	ID requested
1	2019-12-06 14:02:55	announced
⏵ 2	2024-10-22 04:48:38	announced	2024-10-22: Updated project metadata.

Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I, PP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction. J Alzheimers Dis, 72(1):229-246(2019) [pubmed]

10.3233/JAD-181171;

submitter keyword: APP/PS1 mice,Alzheimer’s disease, Brain, Vitamin E, Tocotrienol-rich fraction

Ikuo Tooyama
contact affiliation	Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan
contact email	kinchan@belle.shiga-med.ac.jp
lab head
Hamizah Shahirah Hamezah
contact affiliation	Molecular Neuroscience Research Center, Shiga University of Medical Science
contact email	hamiza49@belle.shiga-med.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD011068

PRIDE project URI

• PRIDE
  1. PXD011068
     1. Label: PRIDE project
     2. Name: Proteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction